#Super strain syphilis skin
endemicum (TEN), which cause yaws and bejel, are transmitted through skin contact and show similar clinical manifestations.īy using genome-wide data, the researchers were able to reconstruct a phylogenetic tree showing a clear separation between the TPA lineage and the TPE/TEN lineage. pertenue (TPE) and Treponema pallidum subsp. Like syphilis bacteria, the closely related subspecies Treponema pallidum subsp. The team collected 70 clinical and laboratory samples of syphilis, yaws, and bejel infections from 13 countries spread across the globe. Because clinical samples from syphilis patients only contain low quantities of treponemal DNA and the pathogen is difficult to culture in the laboratory, researchers from the University of Zurich decided in 2013 to apply DNA capture and whole-genome sequencing techniques, as used by colleagues at the University of Tübingen, to ancient DNA samples. Yet the reason for the resurgence of this sexually transmitted infection remains poorly understood.Īccording to the authors of the paper, little is known about the patterns of genetic diversity in current infections or the evolutionary origins of the disease. pallidum (TPA) has been re-emerging globally in the last few decades more than 10 million cases are reported annually. Strikingly, however, infection with the bacteria Treponema pallidum subsp. When treatment with the antibiotic penicillin became available in the mid-twentieth century, infection rates started to decrease dramatically.
After the first reported outbreaks struck Europe in 1495, the disease spread rapidly to other continents and swelled to a global pandemic. Syphilis has plagued humankind for over 500 years.
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